The LEF supplement provides 100 mcg of MK-7. I am very conscientious of my diet and eat very, very few processed foods. Strontium ranelate was used in these trials. Hi Carol, If you end up finding your vit D3 needs run even higher to 10,000 IU/day you could check out Life Extensions vitamin K supplement, which is what I use for my additional K2 since I must take 10,000 IU/day of D3. I have not added the MCHC to my regimen yet. Were so pleased to hear youre finding the information on our blog helpful. Magnesium (as Phosphate) 21mg What are her vitamin D levels her (25(OH)D blood levels? Three types of strontium salts are in use today: (1) Natural stable strontium, e.g., strontium citrate, (2) Unnatural stable pharmaceutical strontium called strontium ranelate, and (3) Radioactive (unstable) strontium. . https://www.algaecal.com/shop/ I take a PPI for stomach ulcers which is time release and works for 24 hours. I found your product and started taking it this week, however when I take the Strontium at night, I get this weird pain in my right thumb, where the thumb joins the hand and I cant use it to lift anything it is very weird. Also, sometimes crystals can form and deposit in a joint a thumb joint version of gout. topic. Since you are taking AlgaeCal Plus and thus getting at least twice as much calcium as strontium, you are never going to absorb more strontium than calcium. First, its best that you stop taking any Strontium Boost until you have no symptoms. Synthroid is FDA pregnancy category A - it is definitely secure for breastfeeding Synthroid or Levothyroxine in its generic form, is a a commonly used medication to treat Hypothyroidism, an underactive thyroid. PLEASE ANY IFO WOULD BE GREAT SHES SCARED AND HEARTBOKEN, Hello Amanda, I do have mild osteoporosis.. Sorry, do not mean to hammer on you with questions. You can learn more about our human clinical trials HERE. As the daily dose of Strontium Boost is 4 capsules, it would be easy to cut down to half (2 caps) or 1/4 (1 capsule). Full days serving of AlgaeCal Plus is 4 capsules 2 capsules twice daily. If you do not wake up at night, you can take your strontium during the day you just want to take it when you are not also consuming calcium, so with a breakfast or lunch that does not contain calcium. So are you comfortable with me taking 2 of the AlgaeCal daily as I was hoping to up by strontium to 2 daily. Yes, your DXA BMD score will be impacted by strontium. Spector. As always, take strontium separate from your calcium intake. Please clear this up and let us know whether taking the two minerals separately just allows both to remineralize bones, or causes strontium to replace the calcium in bones. I have been taking only 2-3 a day, and one strontium tablet. I have some older bottles(2 years) of strontium citrate3 caps = 750mgs. Personally, I expect to no longer be even borderline osteopenic by my next DXA (about 9 months from now) and as soon as that happens, I am going to run an n=1 trial, cut my strontium dosage in half and see how that works for me. Hope this helps! Re #2, following are the citations of a few of these papers (all are available on PubMed) with my italics added for emphasis and my comments on the relevant text: Im 63 years old, too isnt is great how much fun it is to be all grown up now that we can stay strong and healthy! Where did you read that estrogens might decrease strontium metabolism? As always, thanks for what you do. Hi Lara. 2012 Mar;41(3):92-9.PMID: 22396920) The most recently published human study that discusses strontiums incorporation into trabecular versus cortical bone is Moise H, Chettle DR, Pejovi-Mili A. Expert Opin Drug Saf. (2002). Kind regards Minor bone loss starts at age 40, increasing to 0.5% to 0.9% a year in peri-menopausal women and to above 1% after menopause, after which the yearly loss in BMD remains about 1%. Not to worry, this can be rectified! One capsule gives us 118 mg of strontium and 220 mg of citrate. Bottom line here for practical purposes i.e, YOUR HEALTH, it is not best to simply now rely on the RDI % to determine whether a supplement is providing what YOU need particularly in the case of vitamin D, a blood test to check your levels of 25(OH)D is essential and should be run every 3-6 months for at least a year to get an indication of how the seasons affect YOUR vit D levels depending upon where YOU live, YOUR lifestyle, diet, genetics, etc. The issue is not bone mineral density, but the bodys exposure to estrogens when they are being metabolized into pro-inflammatory, potentially carcinogenic derivatives. Urinary strontium and the risk of breast cancer: a case-control study in Guangzhou, China. Trabecular bone is the soft, spongy, more metabolically-active inner portion of our bones. Radioactive strontium isotopes (85Sr and 89 Sr) are also used as delivery agents for chemotherapy drugs and for diagnostic purposes in kinetic studies. This appears to be how calcium is characterized on the AlgaeCal Plus label (it shows 360 mg of calcium from algas calcareas), and your referral in one comment to the 720-mg daily dose of calcium. I am active and healthy otherwise, on no other medication. Magnesium needs are increased by stress. She lectures at medical conferences around the world and is a contributing author to the Textbook of Functional Medicine, the Textbook of Natural Medicine (Osteoporosis chapter, 5th edition, published 2020), and Integrative Therapies for Depression; co-author of The Encyclopedia of Healing Foods, and lead author of Natural Medicine Instructions for Patients; Your Bones: How You Can Prevent Osteoporosis & Have Strong Bones for Life, Naturally, and her latest book, Healthy Bones, Healthy You! Factors that raise a womans GAIL score are starting menstruation early (so more exposure to estrogens), age at first live birth (pregnancy and nursing lowers estrogen exposure for at least a year, longer if nursing), number of breast biopsies (checking b/c of indications of breast cancer), a history of atypical hyperplasia (abnormal excessive replication of breast tissue cells), and a history of lobular carcinoma in situ (breast cancer). Should strontium citrate be taken indefinitely? Ive been taking AlgaeCal for a few years but stopped the Strontium last November because my husband thought it might be causing the all-over body aches I was having. Thank you, Thanks for reaching out with your question, Mallika! Keep me posted, Lara. Thanks! Just received today my 3 months supply of Algae Cal Plus and Strontium but havent started taking them yet. What do you recommend for me age 74 with fine bonesand osteoporosis with the above BMD results? This emphasizes the value, as antiosteoporotic treatment, of SR, which is safe at the bone mineral level. PMID: 25293384; PMCID: PMC4187454. The most recent study showed higher levels of DHEA were associated with 0.49% less bone loss at the neck of the femur (Ghebre MA, Hart DJ, Hakim AJ, et al. Hes not a Bastyr grad, but Joe recommends him; he is a very good doctor. the only Ca complex to increase bone density in adults! Be sure to check your multivitamin as well to ensure there is no more than 150 mg of calcium. Strontium citrate is 31% elemental strontium and 69% citrate. Strontium ranelate: dose-dependent effects in established Strontium is best taken at night at least two to three hours after a meal or any calcium. Your article clearly shows that strontium and calcium should be taken separately. From the research I have seen on algae-derived calcium, it is more bioavailable and more effectively used in building bone than calcium derived from rock. But in this paper, the results they report suggest overestimation of improvement in BMD in the spine may be ~50%. Hi Lara, Thanks for your reply. When a combined amino acid compound has been introduced to your NAC arrangement, please also consume it when your stomach is empty, just at another moment of the day than the NAC plan. Hi Marilyn, wowthanks so much for taking the time to send me such a complete picture of whats going on with you! Strontium is a mineral thats used to enhance bone mineral density along with calcium. Symptoms of DRESS syndrome typically begin 1-8 weeks after exposure to the medication. Continue to nourish your bones and your entire body well every day for the rest of your long, and healthy life! These may include fatigue, confusion, stomach and back pain . (Oxidative stress promotes inflammation, which then triggers osteoclasts, the specialized cells that break down bone, to spring into action.) BE WELL! And basically following a low carb diet otherwise. Quick follow-up questions. Calcium is present in varying amounts in lots of foods and is high in dairy products. Yes, my inflammation is under control. It remains unanswered in response above! I dont want to do something that would cause other problems. Just prefer not to take anything that may have side effects. Venous thromboembolism (VTE) refers to life-threatening blood clots in deep veins. I am having some issues with plantar fasciitis and possible arthritis in both thumbs. You can get it at the following link. For my post on strontium on AlgaeCal.com, I did review more than 70 studies, but not all the studies I cite there apply specifically to your question about an appropriate maintenance dose of strontium for you. Re AlgaeCal Plus your bones, which are continually remodeling throughout your life, will always need the calcium, magnesium, boron, K2, D3 and trace minerals this supplement provides. The immune system may react more strongly to some bacteria, such as those that cause lyme disease (borrelia burgdorferi), than others. Ive noticed in your previous posts that you take your strontium with lunch. Happy Thanksgiving to you, too. Vit D3 increases your bodys production of vit K dependent proteins, so you will make more of them and will need more K2 to activate them. Or dont bother. This would be 1,500 mg of calcium per day, which is greater than the 1,200 mg RDI for calcium for postmenopausal women. 6. If you get your medications from a reliable pharmacy, ask your pharmacist to double-check for you. To all our good health Shaine, Hi Shaine, Thanks You are so welcome! That being said, your note suggests to me that if you have not already had your vitamin D levels checked, you should do so! You have given some tips how much of dosage we have to take. Hi Patricia, Hi Lynn, This is quite unusual and definitely not something we would expect. Should I take full dose or maybe half? At this point every 2 years does not make sense. WEIRD! Meunier PJ, Slosman DO, Delmas PD, Sebert JL, Brandi ML, Albanese C, Lorenc R, Pors-Nielsen S, De Vernejoul MC, Roces A, Reginster JY. Japanese Natto (fermented soybeans) has extremely high concentrations of vitamin K2 and packets of frozen natto are available at low cost from Asian food shops. In brief, check this persons credentials (where did this man get his medical training? If you are concerned about this, have either the MVL test or the DUTCH test run to check how your estrogens are being metabolized. As soon as I stopped taking the Calcium Citrate, the thumping stopped. Whats adequate vitamin D3? They affect the skin, liver and immune system precisely the organ systems where these ADRs caused by ranelic acid occur. have soya yogurts [ Ive suffered from 1/2 hourly hot flushes for 5 years]. As a result, a treatment with Strontium should not induce any alteration of bone mineral.. I hope this answers your question I realize I sound like a broken record here, but the point is that even though SOTI and TROPOS showed beneficial effects on bone from strontium ranelate, we can have these benefits using a natural form of strontium (like strontium citrate) without the health risks (and high financial costs) of taking the patent medication. You should take it with water 30 minutes before eating breakfast. 2015 Mar;29(3):607-8. doi: 10.1111/jdv.12407. Please feel free to contact our Bone Health Consultants 7 days a week at 1-800-820-0184 (USA & Canada, toll-free) or email [emailprotected] for more information and personalized support! Bone. The perfect time for NAC consumption is about thirty minutes . Meunier, P. J., Slosman, D. O., Delmas, P. D., Sebert, J. L., Brandi, M. L., For those with a zinc deficiency, it's best to take your supplement - such as Care/of's zinc - with food. Since your supplement is giving you 750 mg of strontium in 3 capsules, it looks like you are taking a different strontium citrate supplement. The derivation of this figure has not been published, but the results shown in Table 1 suggest that it is an average of the figures of 41% and 66% derived from the SOTI and STRATOS studies assuming a BSC (bone strontium content) ratio of Rspine 50.61. So, somewhere between 41-66% is overestimation AND that also means that somewhere between 34-59% is actual improvement in BMD. In the section above with the subhead, Adverse Side-effects Are Seen ONLY with Strontium Ranelate Natural Strontium Salts, Like Strontium Citrate are Safe, I explain that the latest research confirms that strontium ranelate increases risk for VTE. Why is it so much more effective? I have read your book,Your Bones and not really found a specific answer to this question . [emailprotected]. Hope this helps. PMID: 24434614 Just be sure to have wild caught rather than farm-raised salmon. Strontium was dose-dependently incorporated into bone mineral of both trabecular and compact bone, mainly into new bone, and mainly into trabecular boneNo changes in the crystal lattice, in crystallinity, or crystal structure were observed. Lara Let me know how you do. So when we take strontium if our diet is not providing adequate magnesium, we may need a bit more magnesium to maintain the optimal 2:1 balance between calcium and magnesium this is the provided in AlgaeCal Plus. I expect it may not be possible for you to ask for strontium in its natural form of strontium citrate, rather than the drug form, strontium ranelate? I was wondering what your opinion on giving dogs canned sardines in water is. Can you clarify which type of strontium was used in these trials? (4 replies) Dosage of Strontium. Fat-soluble vitamin supplements will be harder to absorb on an empty stomach, and they can also lead to an upset stomach. I have been taking strontium citrate for 10 years. I take the Nutralife Calcium with VitD3 and VitK. I agree with you that long-term use of strontium citrate at the full dosage may not be optimal, and why risk it? Strontium is a . So, now I will take it on an empty stomach. Lara. Many factors in our current environment prevent us from getting sufficient iodine for optimal thyroid function. This is the dose that has been used in almost all the human research conducted on stable strontium salts. PURPOSE: To study the correlation of intestinal absorption for drugs with various absorption routes between human and rat, and to explore the underlying molecular mechanisms for the similarity in drug intestinal absorption and the differences in oral bioavailability between human and rat. https://www.ncbi.nlm.nih.gov/pubmed/?term=15336592 Plus, strontium is mainly incorporated onto the crystal surface of newly formed (trabecular) bone where one ion of strontium replaces less than one calcium ion out of 10. The only issues with strontium citrate (or any form of strontium) are that to err on the side of safety, you should be consuming twice as much calcium (from both diet and supplements) as strontium AND you should take your strontium supplement several hours before or after consuming calcium. The expiration date for your supplement should be listed on the bottle. (Here is the reference for this study: Ma B, Zhang Q, Wang G, et al. Were so sorry to hear about your experience, Maureen. Injection-site reactions (such as redness or swelling around the injection site) are common with Boniva injections. As you can see from the references listed below, in the Niu et al. It turns out that citrate is a favorite food for Clostridia (C.difficile). Will definitely not eat any more yogurt as that was just a sugar splurge. The information on the strontium/thyroid is found in the Lis thesis paper cited above. However and this is why I am unable to tell you exactly how much strontium is deposited in cortical and in trabecular bone in real individual people the strontium signal varied widely between individuals such that after three years, the highest strontium signal observed was 28.15 for the finger (cortical bone) and 26.47 for the ankle in one volunteer and only 3.15 for the finger (cortical) and 4.46 for the ankle (trabecular) bone in another. As always, grateful to you! This is the only change I made to what I had been doing. Please take a look at my post titled Commonly Prescribed Drugs Cause Bone Loss and check any drugs you regularly take to see if they have this adverse side effect (https://blog.algaecal.com/prescription-drugs-that-cause-osteoporosis/). Abstract Since natural minerals cannot be patented, Servier developed a chemical drug form of strontium called strontium ranelate. Modern wheat has been greatly hybridized over the last 50 years and contains WAY more gluten (gliaden) than wheat used to, and the food industry now also deanimates wheat to make it water-soluble, and thus easier to use in producing products. I did notice something interesting on the label though. All three AlgaeCal Plans tested produced increases in BMD a marked improvement over just slowing the rate of age-related bone loss. I am happy to suggest some choices of natural strontium supplements for you. Women using HRT were shown to have higher BMD and also greater risk of breast cancer. The reasons for this are that failing kidneys lose their ability to: So, if you are on dialysis or have end stage of kidney failure, ask your doctor for advice on whether to proceed with strontium supplementation. I am concerned when I read that too much strontium can cause softening of the bones. I was wondering if you had seen this article from Univ of Toronto, re lyme (borrelia burgdorferi) causing bone loss? If you would like to learn more about K2, Ive written a review for physicians of the latest research on this nutrient; youll understand the key points despite the medical jargon its available via this link: No research indicates that strontium citrate would cause problems for someone with coronary artery disease; however, this is something you should definitely discuss with your doctor before taking strontium or calcium for that matter. Heres my reply: An overgrowth of bacteria such as Clostridium difficile may also be the cause. Its usually a Friday or Saturday night treat for him. Hi Todd, I do not know her personally, but she is a member of the Institute for Functional Medicine a very good sign, the doctors involved with the IFM are both better informed and more open to integrative medicine. The only red flag I received was for Strontium. 17, no. Ranelic acid is a new to nature compound, synthesized in a lab by a pharmaceutical company so they could combine it with strontium and thus patent the result the purpose of this is to make money, no other reason. Within 3 hours, you will have digested the yogurt and absorbed the calcium in it. In fact, there has been so much research indicating vit D plays a very important role in our muscular stability that two very large trials are now in progress to sort out the best specific recommendations for how much vit D and how much calcium is optimal here are two papers discussing these studies one is being conducted in Spain, the other in Finland: We are so fortunate to have access to the discoveries in the medical research about what our bodies need to remain healthy many of these insights have only surfaced during the last 25 years. Heres a link to my talk on TBS: https://blog.algaecal.com/how-to-analyze-your-dexa-results-for-bone-quality/ The really good news is that your DXA images can be used to calculate your TBS, so please request that this be done for you when you go in for your next DXA. Another quote from this paper on spine BMD improvements being most likely to be over-estimated . Hi David, Lara has forwarded her response to us. The Sr content greatly decreased (about 2-fold) in animals killed 6 or 10 weeks after the end of treatment but this affected new bone almost exclusively. And is Boron safe in your opinion? One very important factor to consider is vitamin A. Vitamin A is the key nutrient required for immune tolerance (vitamin A is involved in causing the immune system to produce regulatory T cells of the IL-10 strain, which help tune down and resolve inflammation), and many of us are not getting adequate vitamin A, which also works in partnership with vitamin D and should be consumed in comparable amounts for the optimal benefits derived from both nutrients. However, do remember to take your Strontium Boost with a snack that does not contain calcium an apple, a couple of whole grain (preferably gluten-free) crackers, a handful of nuts (peanuts, pumpkin seeds, sunflower seeds are fine; almonds, walnuts, cashews, sesame seeds contain calcium, so not your best option a snack when taking Strontium Boost). 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